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This episode examines Meta’s strategic shift from open source to proprietary licensing with its Mango and Avocado models, scheduled for first half twenty twenty six release. We cover Insilico Medicine’s Science MMAI Gym, a reinforcement fine tuning environment that converted baseline frontier models from seventy to ninety five percent failure rates on drug discovery tasks to state of the art performance through domain specific reward modeling. The briefing analyzes a four hundred and eighty million dollar seed round funding multi agent coordination architectures at Humans ampersand, Marine Corps platform consolidation onto GenAI dot mil, TriNetX’s conversational AI deployment for clinical trial feasibility, and OpenAI’s first hardware product targeting ambient intelligence. These developments demonstrate continued divergence in training objectives, licensing strategies, and enterprise deployment patterns across production AI infrastructure.