This episode examines four distinct deployments of domain-specific AI infrastructure. Basecamp Research’s EDEN models, trained on over ten trillion tokens of evolutionary DNA using one thousand eight Hopper GPUs, achieved complete coverage across tested genomic insertion sites with laboratory-confirmed therapeutic applications. Luminary Cloud released three Physics AI models reducing defense engineering analysis from hours to seconds for collaborative combat aircraft, submarine design, and fluid systems within secure U.S. infrastructure. Apple announced a multi-year collaboration structuring its next-generation Foundation Models on Google’s Gemini technology while maintaining existing device and privacy architectures. NVIDIA and Eli Lilly established a co-innovation lab integrating DGX systems with Clara Discovery for AI-driven pharmaceutical research workflows. These developments demonstrate divergent approaches to model development, from proprietary dataset generation at frontier scale to foundation model licensing and sector-specific computational integration.